Technology for License...

We have a number of patent protected, in-vitro diagnostic technologies which are available for license or co-development. For further information, please contact us here.

Method for Rapid Microbial ID and AST

Traditional methods of microbial ID/AST depend upon the growth and replication of microorganism over many microbial generations, which requires a relatively long incubation. Other techniques of looking at the effects of antibiotics on single organisms has been attempted for many years but has generally proven ineffective. We have developed and patented a technique for digitally analyzing statistically significant numbers of microcolonies growing on a thin-film substrate, which provides accurate microbial ID and microbial MIC inless than two hours. This technology has been successfully tested for a large number of bug/drug combinations and has produced results equivalent to standard reference methods, even with organisms which take several generations to manifest resistance. This technology is extensively patented; a more detailed description can be seen here.

Simple Technique for Detecting Rare Circulating Cells, Including Carcinoma Cells and Hematoparasites

The QBC® Malaria Test is the recognized gold-standard for testing for hematoparasites, which operates by centrifugally separating and physically isolating the organisms into an optically viewable region of the tube. Laboratory tests have shown that the technique can detect a single organism in the 100 µliter blood sample within the tube. Because cancer cells and some hematoparasites such as the trypanosomes of Chaga's disease circulate in much fewer numbers, we, along with researchers at Battelle Memorial Organization have developed a special technique which can process 10 ml of blood and concentrate, isolate and identify any circulating cells or organisms therewithin. In constrast to magnetic separation methods, this technology is simple, and the separation and identification can take place within the same tube without the need for any particular expertise or technique on the part of the operator.

This technology may be used for staging carcinomas or determining the patient's response to chemotherapy. There is also the potential for its use as a general screening procedure to detect early carcimomas. Clinical studies are ongoing. This technology is extensively patented; a PDF file of the Battelle Poster presentation of the technology can be downloaded here.

Method for Rapidly Identifying and Enumerating Viral or Other Pathogens

This technology enables the rapid detection and enumeration of any genetic unit from which a replicating ligand can be produced. A sample is placed on a thin gel film containing the appropriate base sequences, and rapid replication of the target fragments occurs in-situ, creating micro-colony like features which are detected and counted by an imaging system, giving quantitative results. Multiple targets can be simultaneously detected. This technology is patented; a more detailed description can be seen here.

An Expert System for the Interpretation of Thyroid Function Tests

An expert system was developed for the interpretation of thyroid function tests and suggestions for any follow-up tests required in borderline cases. The system works with laboratory results, either input manually or from an instrument performing a basic thyroid panel, to provide the physician or other health care worker with differential diagnostic possibilities, along with, if requested, references to the relevant literature and suggestions for follow-up action. The system was extensively vetted by several internationally recognized experts in the field of endocrinology. Potential uses include support services or sales incentives for large reference laboratories serving the human medical market.

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